Dexamethasone suppression test in schizophrenia: Relationship to symptomatology, ventricular enlargement, and outcome
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منابع مشابه
Dexamethasone suppression test in schizophrenia: relationship to symptomatology, ventricular enlargement, and outcome.
To relieve confusion about the clinical correlates and prognostic implications of the dexamethasone suppression test (DST) in schizophrenia, we conducted a DST in 44 schizophrenic inpatients at drug-free baseline and approximately 4 weeks after neuroleptic treatment. Patients were rated on positive, negative, and depressive symptoms at both times. A head computed tomography (CT) scan was perfor...
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Baseline plasma Cortisol levels and response to dexamethasone in a group of twenty five patients with ma) or depressive disorder (MDD) and a control group of twenty five patients with psychiatric diagnoses other than MDD were estimated. The results of our study show that dexamethasone suppression test (DST) is a useful diagnostic aid in MDD with melancholia with a sensitivity of 46% and specifi...
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Although the Dexamethasone Suppression Test (DST) was originally proposed as a specific marker for major depressive disorder (Carroll et al. 1981), several recent studies have reported high rates of DST nonsuppression in schizophrenic patients, ranging from 22% to 73%. DST nonsuppression in schizophrenia has been attributed to depressive symptomatology (Munro et al. 1983), negative symptomatolo...
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To determine whether children who demonstrate dexamethasone suppression test (DST) nonsuppression have lower plasma dexamethasone levels than DST suppressors, we administered the DST to 73 patients ranging in age from 5-14 years. Plasma dexamethasone levels and postdexamethasone cortisol levels were measured at 4:00 PM on day 2. We found: (1) DST nonsuppressors had significantly lower plasma de...
متن کاملVentricular enlargement, neuropsychological status, and premorbid function in schizophrenia.
Ventricular enlargement is one of the most consistently documented neurobiological abnormalities in schizophrenia. The timing of the development of this abnormality in the course of schizophrenic illness and its relationship to neuropsychological dysfunction and premorbid adjustment is, however, unclear. To address these questions, we examined the relationship between ventricle-brain ratio (VBR...
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ژورنال
عنوان ژورنال: Biological Psychiatry
سال: 1991
ISSN: 0006-3223
DOI: 10.1016/0006-3223(91)90353-n